Cardiovascular diseases (CVDs) continue to dominate global mortality statistics, claiming nearly 18 million lives annually. This foundational session at the World Cardiology Conference (WCC 2026) will explore the full clinical spectrum—from ischemic heart disease and cerebrovascular conditions to peripheral artery disease and hypertension. Experts will dissect the intersection of lifestyle, socio-economic factors, and comorbidities, while proposing integrated care pathways and scalable models for low-resource settings. The session will also spotlight the latest research, guideline updates, and policy strategies for population-level impact.