Lipid disorders remain a primary driver of atherosclerosis and cardiovascular events. This session at the World Cardiology Conference (WCC 2026) will examine advances in lipid-lowering agents including statins, PCSK9 inhibitors, bempedoic acid, and siRNA therapies. Focus areas will include lipid metabolism, plaque biology, imaging of subclinical atherosclerosis, and residual inflammatory risk. Clinical strategies for managing familial hypercholesterolemia and combined dyslipidemia will also be discussed.